MK-677 | 100 x 10 mg

SAFETY DATA SHEET

Ibutamoren, also known as MK-677, is an orally active, long-acting growth hormone secretagogue that mimics the action of ghrelin by binding to the ghrelin receptor (GHS-R1a) in the brain. This results in a sustained, dose-dependent increase in circulating growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels without significantly affecting cortisol or prolactin secretion. Unlike recombinant GH administration, MK-677 stimulates natural pulsatile release of growth hormone, which may preserve physiological feedback mechanisms and receptor sensitivity.

In clinical and experimental settings, MK-677 has demonstrated the ability to:

• Facilitate increases in fat-free mass and enhances nitrogen balance in preclinical models
• Modulate IGF-1-mediated signaling pathways implicated in skeletal muscle regeneration and tissue repair
• Demonstrate potential to influence bone mineral density parameters, particularly in age-related research contexts
• Affect sleep architecture and REM phase duration, likely through central ghrelin receptor (GHS-R1a) activation
• Alter gene expression and signaling cascades associated with dermal, follicular, and extracellular matrix dynamics in regenerative biology models

Ibutamoren’s oral bioavailability, extended half-life, and minimal suppression of endogenous hormone production make it an attractive candidate for long-term research into GH-related therapies, sarcopenia, and age-associated decline in anabolic hormones.

⚠ Important Note: This product is supplied strictly for laboratory research use only. It is not approved for human consumption or therapeutic use. Not intended to diagnose, treat, cure, or prevent any disease.